Agilent launches new SureGuide CRISPR activation and interference libraries

Agilent Technologies has announced the launch of new SureGuide pooled libraries for CRISPR activation and interference.

The latest additions to the company's range of pooled SureGuide CRISPR libraries for functional genomics will be created using Agilent's advanced SurePrint DNA synthesis platform, with billions of DNA bases printed with fidelity and superior representation.

Whereas CRISPR knock-outs target individual genetic regions, CRISPR activation and interference libraries target transcription start sites throughout the genome, allowing researchers to modulate the expression of individual genes and screen the resulting phenotypes.

The libraries will be offered in both Ready-to-Clone and Ready-to-Amplify formats, with the former allowing users to specify the sequence of each guide or choose from predefined subsets, and the latter letting them fully design every aspect of the library.

Kamni Vijay, vice-president and general manager of Agilent's genomics solutions and clinical applications divisions, said: "This expansion of our SureGuide portfolio is an example of Agilent's continued commitment to enabling new discoveries using CRISPR technology."

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