Antibody treatment may represent major Alzheimer’s breakthrough

Tests carried out by the Washington University School of Medicine may have produced a major breakthrough in the fight against Alzheimer's disease, after studies on mice found an antibody could remove the brain plaques associated with the disease. 

Researchers found that applying a DNA-based antibody compound to Alzheimer's protein APOE not only removed this but also the sticky amyloid beta plaques that build up in the brain prior to the onset of the disease and provide a host environment for APOE.

The discovery, published in the Journal of Clinical Investigation, may pave the way for treatments that could remove the sticky plaques in patients before any symptoms appear, reversing or at least halting the brain damage they cause. 

Senior author of the study David Holtzmann said: "By removing plaques, if we start early enough, we may be able to stop the changes to the brain that result in forgetfulness, confusion and cognitive decline."

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