AstraZeneca expands cancer research collaboration with Myriad Genetics

AstraZeneca has announced that it will be expanding its ongoing collaboration with Myriad Genetics to include a new companion diagnostics agreement.

The firm will be using Myriad Genetics' myChoice HRD Plus testing system in an exploratory analysis to identify women with advanced ovarian cancer who may benefit from maintenance treatment with Lynparza and Avastin.

Under the terms of the deal, myChoice HRD Plus will be used to evaluate patients enrolled in an ongoing phase III trial, with the specific aim of identifying cases with homologous recombination deficiencies.

Myriad Genetics' test offers a comprehensive solution for detecting tumours that have lost the ability to repair double-stranded DNA breaks, meaning they are unusually susceptible to DNA-damaging therapies such as platinum drugs or PARP inhibitors.

Dr Jerry Lanchbury, chief scientific officer for Myriad Genetics, said: "We are excited to continue our collaboration with AstraZeneca and to apply innovative new technologies like myChoice HRD Plus to increase the number of patients who may benefit from Lynparza."

AstraZeneca and Myriad Genetics have been working together to create novel companion diagnostic tests since 2007.

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