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Home Industry News Bioverativ reports positive data from long-term study of Alprolix

Bioverativ reports positive data from long-term study of Alprolix

3rd March 2017

Bioverativ and its partner Sobi have announced new clinical trial data supporting the long-term benefits of Alprolix in the treatment of haemophilia B.

Results from the B-YOND extension trial have demonstrated the safety and efficacy of the drug in previously-treated subjects with severe haemophilia B over an extended period of time. 

Data published in the medical journal Thrombosis and Haemostasis showed that prophylactic treatment with Alprolix over a median duration of more than three years resulted in zero patients developing inhibitors, the neutralising antibodies that can interfere with successful therapy.

B-YOND represents the longest-term study of an extended half-life therapy for haemophilia B conducted to date.

Dr Maha Radhakrishnan, senior vice-president of medical at Bioverativ, said: "These results confirm the long-term safety and efficacy profile of Alprolix and show that a majority of the participants in the study were able to dose once weekly or less frequently while maintaining adequate protection."

Bioverativ commenced life as a standalone company a month ago, having been spun out from Biogen to operate as a dedicated haemophilia-focused business.

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