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Home Industry News Bristol-Myers Squibb stops cancer drug trial early due to positive performance

Bristol-Myers Squibb stops cancer drug trial early due to positive performance

8th September 2017

Bristol-Myers Squibb has announced that its CheckMate-214 study cancer study is set to be halted early.

The phase III study is evaluating a combination of Opdivo and Yervoy in patients with previously untreated advanced or metastatic renal cell carcinoma, with the regimen demonstrating superior overall survival in intermediate and poor-risk patients.

It meant that the regimen met its primary efficacy endpoint, while the combination also met its secondary endpoint of improved overall survival across all randomised patients.

Based on a planned interim analysis of the findings, an independent data monitoring committee has recommended that the trial be stopped early.

Dr Vicki Goodman, head of new asset development at Bristol-Myers Squibb, said: "This overall survival result from CheckMate-214 highlights the potential of the combination of Opdivo and Yervoy to provide a new treatment option for first-line advanced renal cell carcinoma patients, for whom there is a considerable unmet need."

Results from this study will be shared with regulatory authorities and presented by the company at the European Society for Medical Oncology Congress.

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