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Home Industry News Dionex describes M6P determining method

Dionex describes M6P determining method

13th October 2008

Dionex has described its new method for confirming the presence of mannose-6-phosphate (M6P) in a glycoprotein and determining its amount in an application note.

High-Performance Anion Exchange Chromatography with Pulsed Amperometric Detection Analysis of Mannose-6-Phosphate – application note 202 – maps out how the amount of M6P in a glycoprotein can be determined using electrochemical detection, Carbopac analytical columns and an ICS-3000 ion chromatography system.

The new method fully resolves M6P and M1P (mannose-1-phosphate), Dionex said, as well as M6P from the protein acid hydrolysis products produced during the release of M6P from glycoprotein.

Dionex described M6P as an "important intermediate in glycoprotein production". A number of congenital disorders may result from deficiencies in it, making M6P-containing proteins "an active area of medical research".

The news may be of interest to people looking for their next scientific sales jobs, who may also want to attend one of many water analysis seminars held by Dionex throughout the autumn.


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