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Home Industry News Forest Laboratories collaborates on two new CNS drugs

Forest Laboratories collaborates on two new CNS drugs

1st December 2005

Forest Laboratories has announced that it has entered into two new collaboration agreements involving two novel mechanisms targeted for the treatment of various central nervous system (CNS) conditions.

The company will collaborate with Hungarian firm Gedeon Richter on the development the neuropathic pain killing drug, RGH-896, which is in the first phase of clinical testing in the United States and scheduled for more trials in the second half of 2006.

In addition to neuropathic pain, the companies intend to investigate various other pain conditions and possibly CNS indications not related to pain. RGH-896 represents a novel approach to neuropathic pain by targeting a specific portion of the NMDA (N-methyl-D-aspartate) receptor that may be involved in the transmission of pain.

The second new collaboration will focus upon a group of novel compounds that target the group one metabotropic glutamate receptors (mGLUR1/5). mGLUR1/5 antagonists represent novel, potential agents for the treatment of anxiety, depression and other CNS conditions.

Howard Solomon, chairman and chief executive officer of Forest, commented: “We are delighted to partner with Gedeon Richter in two additional development projects.

“Both companies are particularly focused on CNS drugs, still the most difficult, the most unexplored, the most mysterious and the most needy from the patients’ viewpoint of all therapeutic areas. This transaction will further build on Forest’s expertise in the field of NMDA receptors and the excitatory neurotransmitter glutamate.”

Forest will pay Richter undisclosed upfront and milestone payments in addition to royalties and will have exclusive rights in North America while Richter will retain exclusive rights in Europe and countries of the former Soviet Union.

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