Genetic alteration bolsters intelligence and reduces anxiety in mice

UK researchers have created unusually intelligent mice that are less likely to feel anxiety or recall fear by altering a single gene.

The University of Leeds study made a change to inhibit the activity of an enzyme called phosphodiesterase-4B (PDE4B), resulting in enhanced cognitive abilities, including faster learning, better memory and advanced problem-solving abilities.

PDE4B-inhibited mice also showed less recall of a fearful event after several days, while being less likely to hide in dark, enclosed spaces or showing fear when in the vicinity of feline scents.

It is thought that this research could form the basis for studies of new treatments for age-related cognitive decline, disorders such as Alzheimer's disease and schizophrenia, and other conditions.

Dr Steve Clapcote, lecturer in pharmacology at the University of Leeds' school of biomedical sciences, said: "Cognitive impairments are currently poorly treated, so I'm excited that our work using mice has identified phosphodiesterase-4B as a promising target for potential new treatments."

The researchers are now working on developing drugs that will specifically inhibit PDE4B that may be effective in humans.