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Home Industry News Major new study highlights genes with link to obesity

Major new study highlights genes with link to obesity

15th January 2018

Scientists have identified a number of new genes with potential links to obesity following a large-scale research project.

Conducted by the Genetic Investigation of Anthropometric Traits consortium, the international collaborative saw more than 250 research institutions assessing genetic data from more than 700,000 individuals, drawing upon 125 different studies.

A total of 14 genetic variations were identified in 13 genes, including a risky copy variation – which causes sections of the genome to be repeated – that was associated with an average weight gain of 15 pounds compared to individuals who do not carry the variation.

Furthermore, two variants were found that may affect the function of a gene called GIPR, which were associated with an average weight gain of 4.5 pounds. Eight of the 13 genes identified were newly implicated in obesity.

Dr Ruth Loos, professor at the Charles Bronfman Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai, said: "Our study has provided new potential targets for therapeutic interventions, and may even help personalise treatment for carriers of the genetic variations."

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