Looks like you’re on the UK site. Choose another location to see content specific to your location

Home Industry News New link between causes of arthritis and heart valve disease identified

New link between causes of arthritis and heart valve disease identified

21st July 2015

An inflammatory process responsible for causing rheumatoid arthritis could also play a part in causing heart valve diseases, according to a new study.

Researchers from the Walter and Eliza Hall Institute in Australia have used models to reveal that TNF (tumour necrosis factor), a critical inflammatory protein, could lead to inflammation and disease of the heart valves, including aneurysms.

The link between TNF overproduction and the development of rheumatoid arthritis has been known for many years, but this is the first time it has been associated with heart valve disease.

Study leader Dr Philippe Bouillet, a Walter and Eliza Hall Institute researcher, said: "Our studies suggest that excessive TNF drives heart valve – rather than heart muscle – diseases, and may be worth investigating for inflammatory diseases affecting the heart valves."

Moreover, the scientists were able to determine new regions of the DNA critical for destabilising the molecule, which could lead to the development of better treatments for both diseases.

Additionally, existing drugs that block and remove TNF could now be investigated for treating heart valve conditions.ADNFCR-8000103-ID-801794960-ADNFCR

We currently have 9 jobs available in Pharmacy industry, find your perfect one now.

Stay informed

Receive the latest industry news, Tips
and straight to your inbox.