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Home Industry News New predictor for valvular heart disease identified

New predictor for valvular heart disease identified

13th November 2013

Scientists in Denmark have identified a potentially significant new risk factor for valvular heart disease, which could be used to help prevent the condition in future.

Researchers at the University of Copenhagen, Rigshospitalet and Herlev Hospital have highlighted a clear link between narrowed heart valves – also known as aortic valve stenosis – and a special lipoprotein in the blood. 

The ten percent of the population with the highest levels of lipoprotein(a) in their blood are two to three times more likely to develop the disease.

As such, it could be useful for the pharmaceutical industry to conduct clinical trials that investigate the effect of reducing lipoprotein(a) levels in the body, in relation to aortic stenosis and coronary heart diseases such as myocardial infarction.

Pia Rorbaek Kamstrup, a consultant at Herlev Hospital, said: "Preventative treatments targeted at individuals with very high levels of lipoprotein(a) in their blood can hopefully reduce the number of patients requiring valve surgery and the risks always associated with surgical procedures."

People with severe aortic stenosis who are not treated with surgery have a 25 percent chance of dying within a year of symptoms commencing, with the proportion rising to 50 percent after two years.ADNFCR-8000103-ID-801660327-ADNFCR

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