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Home Industry News New study highlights key variations in bladder cancer subtypes

New study highlights key variations in bladder cancer subtypes

5th January 2012

A Yale University-led study has demonstrated a need for more differentiated research into the two main subtypes of bladder cancer.

Analysis of 128,000 US bladder cancer cases showed that rates of the disease rose by nine percent between 1973 and 2007, but also that an increase in papillary transitional cell carcinoma (PTCC) cases was accompanied by a drop in non-papillary transitional cell carcinoma (NPTCC) diagnoses.

These two types of cancer account for 94 percent of bladder tumours, with similar trends noted regardless of gender, racial background or the stage of disease development.

To date, no epidemiological studies have investigated risk factors for the two subtypes separately, but researchers say the new data shows PTCC and NPTCC may be entirely distinct entities with different causes.

Dr Yawei Zhang from the school of public health and school of medicine at Yale University said: "Our study suggests that future research must make clear distinctions between PTCC and NPTCC and not just treat them as subtypes of transitional cell carcinoma."

According to data from the NHS, bladder cancer is four times more likely to affect men than women, while the average age for new diagnoses is 68.ADNFCR-8000103-ID-801256375-ADNFCR

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