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Home Industry News New technique creates 3D beating heart tissue model

New technique creates 3D beating heart tissue model

22nd February 2017

Scientists have developed the first 3D in vitro cardiac tissue model that incorporates three cell types that can beat together as a single entity.

York University researchers have found a way of creating a scaffold-free composite of three cell types found in the heart – contractile cardiac muscle cells, connective tissue cells and vascular cells – and having them beat together, rather than at different intervals.

An innovative substance called ViaGlue was used to stick the cells together at a millimetre scale. It is believed that larger versions could be made, with a start-up company called OrganoLinX having been set up to commercialise ViaGlue and provide custom 3D tissues on demand.

This breakthrough will provide researchers with improved tools to create and test 3D in vitro cardiac tissue in their own labs, allowing them to gain new insights into heart disease and issues with transplantation.

Professor Muhammad Yousaf, from York University's Faculty of Science, said: "This breakthrough will allow better and earlier drug testing, and potentially eliminate harmful or toxic medications sooner."

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