Potential epilepsy therapies derived from tree resin identified

A new study has demonstrated the potential therapeutic benefits that a number of substances derived from tree resin could provide for epilepsy patients.

Researchers at Linkoping University have synthesised and tested 71 substances known as resin acids, taken from the sticky resin found in conifers, and found 12 that are prime candidates for new medicines.

They are able to interface with ion channels – the pores in the cell membrane that allow for the transport of charged ions, rendering nerve and cardiac cells electrically excitable – in a way that curbs the harmful nerve activity underpinning epilepsy.

With the molecules' effectiveness verified in nerve cells from mice, the researchers have now submitted patent applications prior to continued developmental work.

Fredrik Elinder, professor of molecular neurobiology at Linkoping University and head of the study, said: "It's reasonable for us to be the ones developing the concept further, refining our ideas. But further on, others will have to take over."

It is hoped that these new therapies could be used to relieve or even cure epilepsy later down the line.