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Home Industry News Potential new oral therapy for neurodegeneration revealed

Potential new oral therapy for neurodegeneration revealed

15th October 2013

British scientists have created a compound that could potentially be used to treat and prevent the development of neurodegenerative diseases.

Researchers at the Medical Research Council toxicology unit at the University of Leicester have published data from a new study that builds on a discovery they made last year identifying a major pathway leading to brain cell death in mice.

Using a compound originally developed by GlaxoSmithKline for a different purpose, they were able to block the pathway and prevent neurodegeneration caused by prion disease in the mice.

The researchers noted that the compound was also shown to cause serious side effects, meaning the creation of a usable therapy is a long way off, but this could nevertheless be the first step towards a viable treatment for Alzheimer's and Parkinson's disease.

Professor Giovanna Mallucci, who led the team, said the research "means that developing drug treatments targeting this pathway for prion and other neurodegenerative diseases is now a real possibility".

It is estimated that dementia currently affects around 650,000 people in England, with Alzheimer's disease responsible for around 62 percent of these cases.ADNFCR-8000103-ID-801649743-ADNFCR

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