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Home Industry News Scientists Discover Genes that Enhance Effectiveness of Fecal Microbial Transplants

Scientists Discover Genes that Enhance Effectiveness of Fecal Microbial Transplants

17th October 2023

People with persistent Clostridium difficile infections can manage their illness with fecal microbe transplants.

The majority of fecal microbe transplantation rejections take place a month post-transplant, and virtually nothing is understood about which donor strains offer the best chance of engraftment.

Recently, researchers studying the microbiome at the University of Alabama in Birmingham have discovered that “analysis of the common genes between the three donors revealed that only 19 were in common out of 4,911 genes encoding known and hypothetical proteins. The result from our analysis supports the screening of donor B. vulgatus for this gene consortium to enhance colonization following a fecal microbe transplant.”

Lead researchers Morrow and Koo were able to establish 2/19 genes.

However, “since none of the Human Microbiome Project pairs had the full 19 genes, we do not know whether any of the pairs would have an early colonizing phenotype in fecal microbe transplants.” Morrow said.

“Based on our analysis, we would assume that the commensal colonization factor complex and fimbrillin genes would suffice; but to resolve this issue, additional fecal microbe transplants for recurrent C. difficile in humans using early analysis times post-transplant would need to be done.”

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