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Home Industry News Sesame seed-sized NMR spectrometry device offers drug development benefits

Sesame seed-sized NMR spectrometry device offers drug development benefits

8th August 2014

Future lab research utilising nuclear magnetic resonance (NMR) spectroscopy procedures could be facilitated by the creation of new miniaturised technology by US engineers.

The collaboration between the Harvard School of Engineering and Applied Sciences (SEAS), the Schlumberger-Doll Research Center and the University of Texas has been able to shrink down the electronic spectrometer components on to a silicon chip smaller than a sesame seed.

NMR spectroscopy works by perturbing protons within a molecule to offer insights into how it is structured. It is considered an essential tool in organic chemistry, structural biology and drug discovery.

These miniaturised components can operate accurately over a wide temperature range and could form the basis of new portable NMR spectrometers that can be transported to remote sites for online, on-demand applications, as well as for smaller labs that cannot accommodate larger equipment.

Donhee Ham, professor of electrical engineering and applied physics at Harvard SEAS, said: "Using a hundred of these cheap and small spectrometer chips in parallel within a superconducting magnet bore could counter the intrinsic slowness of NMR spectroscopy, enabling a high-throughput paradigm for pharmaceutical screening and structural biology."ADNFCR-8000103-ID-801740930-ADNFCR

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