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Home Industry News Thermo Fisher Scientific launches range of amino acid derivatives

Thermo Fisher Scientific launches range of amino acid derivatives

12th October 2007

Thermo Fisher Scientific has announced the launch of L-Photo-Leucine and L-Photo-Methionine, two amino acid derivatives that include diazirine rings for ultraviolet light-activated photocrosslinking.

According to the firm, the photo-activatable acids can substitute their respective natural counterparts and are incorporated directly into proteins where they are used to crosslink interacting proteins within native protein complexes.

Photoactivation of the aforementioned diazirine rings within the acids creates reactive intermediaries that crosslink proteins with a zero-length bond, the firm asserts.

And crosslinking takes place within protein-protein interaction domains, resulting in more than 90 per cent recovery of crosslinked proteins after the process of cell lysis.

Using L-Photo-Leucine and L-Photo-Methionine together maximises the probability of crosslinking protein complexes, Thermo Fisher Scientific states.

In recent months, the company announced the launch of the Thermo Scientific Series 8000 CO2 incubators which feature cell culture incubation technologies, advanced decontamination technology as well as humidity, temperature and CO2 control.

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