Gene breakthrough hope for eczema sufferers

Eczema and asthma sufferers have been given increased hope of a cure today with the news that scientists have discovered a gene that causes dry skin.

It is hoped that the discovery could lead to treatments for the common conditions, which afflict many children in the UK.

University of Dundee experts say the gene they have identified produces a protein known as filaggrin, which is responsible for preventing skin dryness. A failure to produce this protein in adequate amounts can lead to dry and flaky skin.

The only current treatment for eczema is through the use of emollients, skin ointments or anti-inflammatory drugs.

One of the researchers, Professor Irwin McLean, from the university’s human genetics department, revealed that the latest study improves scientific understanding of a gene known about for 20 years.

A study of Irish children found that two-thirds with eczema had a defect in the gene and a Danish study showed that more than 60 per cent of children with a defect in the gene developed the condition within the first few years of life.

In another study of children in Scotland, a strong association was found between the gene and asthma.

Professor McLean said: “Analysing this very difficult gene was one of the toughest things we have ever done. Several top genetics labs around the world gave up on it.

“With a mixture of luck, skill, and an incredibly intense team effort over the last few months, we succeeded in unlocking the secrets of the gene and discovered a major cause of the disease.”

It is thought that as many as five million people in Britain are carrying the mutated gene that causes dry, flaky skin and makes them more susceptible to asthma and eczema.

The study is to be published in the journal Nature Genetics.

© Adfero Ltd