Grapefruit drug link revealed

Scientists in the US say they have identified the way in which grapefruit juice impacts upon the efficacy of some medications.

The juice is known for its metabolic properties and as a result patients taking some drugs, in particular those for the treatment of blood pressure or cholesterol-related conditions, should avoid consuming it.

Researchers involved in the study, conducted by the University of North Carolina, have identified an component of the juice called furanocoumarin, which they say reacts with human enzyme CYP3A.

Drugs which are inhibited by the intenstinal enzyme can sometimes enter the blood stream faster if grapefruit juice is consumed as it impacts on the natural function of CYP3A.

Lead researcher Dr Paul Watkins said: “It should now be possible to market the furanocoumarin-free grapefruit juice to patients who would otherwise need to avoid grapefruit.

“In addition, it should be possible to screen new foods for the potential for drug interactions by determining whether they contain furanocoumarins.”

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