NPL-led study achieves biomarker research breakthrough

New research led by the National Physical Laboratory (NPL) has uncovered new findings into the biological processes involved in the identification of biomarkers.

Utilising atomistic computer simulations, the research team was able to identify structural differences between proteins that reveal information about diseases and closely related hormones, which can often cause confusion and unreliable results.

The difference between molecules can often comes down to minute differences of single epitopes, with this knowledge paving the way for new assay technology that utilises intelligent epitope selection to achieve the required results.

Following this initial study involving human chorionic gonadotropin – a hormone produced during pregnancy – it is thought that new immunoassays for related biomarkers can be created, which will aid future pharmaceutical developments.

Max Ryadnov, principal research scientist at the NPL, said: "This work answers one of the big questions in distinguishing biomarkers which are critical for identifying and treating serious diseases."

Earlier this week, the University of Cambridge published a study revealing a new biomarker for autism, which can be found among patients and their siblings.