Tumour-simulating chip offers cancer research potential

Scientists in the US have developed a chip that is able to mimic the biological signature of a tumour – an innovation with multiple potential applications in cancer research.

Led by Purdue University, the project involved the development of a tumour-microenvironment-on-chip (TMOC) system, which allows researchers to study the complex environment surrounding tumours and the barriers that prevent the targeted delivery of therapeutic agents.

Measuring around 4.5 sq cm, it contains microfluidic channels where tumour cells and endothelial cells can be cultured. It also incorporates extracellular matrix, a spongy, scaffold-like material made of collagen found between cells in living tissue.

It represents an alternative to conventional experimental methods, such as studies of cancer cells in petri plates – which do not include the tumour microenvironment – and animal research that does not always translate successfully to humans.

The researchers tested the technology using human breast cancer and endothelial cells, allowing them to gain a better understand of how nanoparticles moved within the microenvironment.

This project was led by Purdue University associate professor of mechanical engineering Bumsoo Han, a recognised expert in the fields of biotransport phenomena and quantitative optical diagnostics.