Novartis study demonstrates heart health benefits of ACZ885

Novartis has announced new clinical trial data that demonstrates the promise offered by its new inflammatory atherosclerosis therapy ACZ885.

Data from the data from the phase III CANTOS study has shown that targeting inflammation with ACZ885 can effectively reduce cardiovascular risk in people with a prior heart attack and inflammatory atherosclerosis.

Quarterly injections of ACZ885 led to a statistically significant 15 percent reduction in the risk of major adverse cardiovascular events compared to placebo, a benefit that was sustained throughout the duration of the study and was largely consistent across key pre-specified baseline subgroups.

Additionally, a review of blinded preplanned oncology safety analyses revealed a 77 percent reduction in lung cancer mortality and 67 percent reduction in lung cancer cases in patients treated with ACZ885

Vas Narasimhan, global head of drug development and chief medical officer at Novartis, said: "We look forward to submitting the CANTOS data to regulatory authorities for approval in cardiovascular and initiating additional phase III studies in lung cancer."

More than 10,000 patients were enrolled in the CANTOS study over the last six years, making it one of the largest and longest-running clinical trials in Novartis' history.

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