Sigma-Aldrich launches transgene integration kit for mouse genome

Sigma-Aldrich has announced the launch of CompoZr Targeted Integration Kit – mRosa26, a new transgene integration kit for use on mice.

The system targets the Rosa26 safe harbour locus in the mouse genome and utilises zinc finger nucleases (ZFN) to allow transgenes to be integrated precisely and rapidly, offering a range of uses for the research community.

It follows the introduction of the CompoZr Targeted Integration Kit – AAVS1 for human subjects and helps to minimise the timescale and complexity of engineering transgenic cell lines.

Dr Supriya Shivakumar, global commercial marketing manager for functional genomics at Sigma Life Science, said ZFN-mediated transgene integration represents the most efficient method of conducting this procedure.

"This latest release is part of Sigma's ongoing objective to increase the research community's access to advanced genomic engineering strategies by offering innovative, easy-to-use products based on our proprietary ZFN technology," she added.

Earlier this month, Sigma-Aldrich's SAFC division launched a new range of ZFN-modified Chinese hamster ovary cell lines for use in life science research.