Integrated DNA Technologies to present new research at AGBT meeting

Integrated DNA Technologies has confirmed it will be sharing its latest research findings at the upcoming Advances in Genome Biology and Technology (AGBT) meeting in Florida from February 12th to 15th 2014.

Dr John Havens, vice-president of business development at the company, will present findings on the use of molecular inversion probes (MIPs) for next-generation sequencing target enrichment. It will address their proven effectiveness in the enrichment of genomic content of biological samples for specific regions of interest.

The company has created a procedure that uses a high-fidelity platform to synthesise MIPs as long as 200 bases, the presence of which can be verified using mass spectroscopy prior to pooling.

Barcodes can then be directly incorporated via degenerate bases and used to characterise the complexity of target capture. MIPs provide high multiplexability of targets in a single tube and can enrich small amounts of DNA, resulting in time and cost-effective sequencing.

Dr Havens will demonstrate the advantage of MIPs in terms of target specificity and the capture of longer targets, specifically highlighting the benefits of MIPs over traditional methods such as hybridisation.

This comes after the firm recently expanded its next-generation sequencing portfolio with the launch of xGen Universal Blocking Oligos, for use in enhancing the performance of target capture experiments.