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Waters introduces new data acquisition mode for Xevo G2-XS spectrometer
Waters has announced the introduction of a new data acquisition mode called SONAR for its Xevo G2-XS quadrupole time-of-flight mass spectrometer (MS).
The SONAR technology allows for the quantification and identification of lipids, metabolites and proteins in complex samples from a single injection, without the additional method development normally associated with MS/MS analysis.
It has been optimised for modern proteomics experiments, in which DIA-based mass spectrometry has become an increasingly popular technique for capturing data-rich sample profiles.
Additional selectivity is enabled by the behaviour of the mass spectrometer's quadrupole, which slides over the selected mass range of interest capturing 200 spectra per scan, instead of remaining open and transmitting all ions.
This makes the SONAR mode compatible with fast UltraPerformance liquid chromatography separations that increase laboratory throughput, allowing compounds that may have chromatographically coeluted to be separated by the quadrupole and recorded individually for more effective library searches.
David Heywood, senior manager for omics business development at Waters, said: "Compatible with high-speed UPLC separations, it's a more efficient workflow for more accurate qualitative and quantitative analysis within a single injection."
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